德克萨斯大学Michael P. Doyle教授系列学术报告——金属卡宾化学

发布日期: 2017-06-29浏览次数:

报告人:Prof. Michael P. Doyle

时间:2017710日下午 14:002017711日下午 14:00

地点:7026威尼斯官网院办一楼报告厅(教四楼)

联系人:沙强

联系方式:13515117536

热烈欢迎各位老师和同学参加!

 

报告题目:

1. Cycloaddition Reactions for the Synthesis of Heterocyclic Compounds 2017710日下午 14:00

2. Exceptional Reactions and Reactivities of Diazo Compounds Accessed Via Gold Catalysis 2017711日下午14:00

 

Michael P. Doyle教授简介:

Michael P. Doyle教授先后执教于霍普学院、三一学院、亚利桑那大学、马里兰大学帕克分校、德克萨斯大学圣安东尼奥分校,现为德克萨斯大学圣安东尼奥分校教授(Professor and The Rita and John Feik Distinguished University Chair in Medicinal Chemistry)。从事金属卡宾化学领域研究三十余年,迄今为止发表论文360余篇,总引用22000余次,H因子73,编写专著11部,由于Doyle教授在硫叶立德的不对称[2,3]-σ重排反应领域的杰出贡献,该反应被冠名为Doyle-Kirmse reaction。其开发的商品化Doyle催化剂已被广泛应用于药物合成中不对称C-H插入反应及环丙烷反应。Doyle教授获得了ACS Arthur C. Cope Scholar Award等多项重要学术奖励和荣誉,2002以来,受邀在全世界范围内进行讲学150余次。

 

近几年代表性论文:

1Deng, Y.; Massey, L.A.; Zavalij, P.; Doyle, M.P. "Catalytic Asymmetric [3+1]-Cycloaddition Reaction of Ylides with Electrophilic Metallo-enolcarbene Intermediates" Angew. Chem. Int. Ed. 2017, 129, 7587-7591. (very important paper) (DOI: 10.1002/ ange.201704069)

2Duan, A.; Yu, P.; Liu, Fang; Qiu, H.; Gu, F.L.; Doyle, M.P.; Houk, K.N. "Diazo Esters as Dienophiles in Intramolecular (4+2) Cycloadditions: Computational Explorations of Mechanism" J. Am. Chem. Soc. 2017, 139, 2766-2770. (DOI: 10.1021/jacs.6b12371)

3Deng, Y.; Yglesias, M.V.; Arman, H.; Doyle, M.P. "Catalytic Asymmetric Synthesis of Cyclopentyl β-Amino Esters by [3+2]-Cycloaddition of Enecarbamates with Electrophilic Metalloenolcarbene Intermediates" Angew. Chem. Int. Ed. 2016, 55, 10108-10112. (DOI: 10.1002/anie.20160543)

4Cheng, Q.Q.; Yedoyan, J.; Arman, H.; Doyle, M.P. "Dirhodium(II)-Catalyzed Annulation of Enoldiazoacetamides with α-Diazoketones: An Efficient and Highly Selective Approach to Fused and Bridged Ring System" Angew. Chem. Int. Ed. 2016, 55, 5573-5576. (cover story) (DOI: 10.1021/anie.201601260).

5Qiu, H.; Srinivas, H.; Zavalij, P.; Doyle, M.P. "Unprecedented Intramolecular [4+2]-Cycloaddition Between a 1,3-Diene and a Diazo Ester" J. Am. Chem. Soc. 2016. 138, 44-47. (DOI: 10.1021/jacs.5b12877)

6Cheng, Q.Q.; Yedoyan, J.; Arman, H.; Doyle, M.P. "Copper-Catalyzed Divergent Addition Reactions of Enoldiazoacetamides with Nitrones" J. Am. Chem. Soc. 2016, 138, 44-77. (DOI: 10.1021/jacs.5b10860)

7Xu, X.; Deng, Y.; Yim, D.N.; Zavalij, P.Y.; Doyle, M.P. "Enantioselective cis-β-Lactam Synthesis by Intramolecular C-H Functionalization from Enoldiazoacetamides and Derivative Donor-Acceptor Cyclopropenes" Chem. Sci.2015, 6, 2196-220. (DOI: 10.1039/ C4SC03991B)

8Truong, P.M.; Zavalij, P.Y.;Doyle, M.P. "Highly Enantioselective Carbonyl-Ene Reactions of 2,3-Diketoesters; Efficient and Atom-Economical Process to Functionalized Chiral α-Hydroxy-β-ketoesters" Angew. Chem. Int. Ed. 2014, 53, 6468–6472. (DOI: 10.1002/ anie.201402233)